Assessment of the Therapeutic Efficacy of Nano-capsules of Albendazole and Mebendazole against hydatidosis in BALB/c Mice

Using nanotechnology, medicine can effectively be made stronger, lighter, more durable, more reactive. In this study, a highly safe emulsion nano-capsule was tested for its superior efficacy, the ability to overcome drug resistance, and the least possible amount of side effects and complications associated with the treatment of hydatidosis. Nano-capsules are synthesized using a micro-emulsion of oil in water. Formulations were tested via droplet size, zeta potential and SEM. Following seven months after infection, hydatidosis-infected ۳۰ mice were divided into three groups. Groups ۱ was treated daily with Albendazole plus Mebendazole Polymer Nano-capsules (Nano-ABZ+MBZ), group ۲ was treated with Albendazole plus Mebendazole (ABZ+MBZ) as a positive control group, and Albendazole as a control group, group ۳ was the negative control group without treatments (only received PBS). According to the results of the study, the total cyst numbers, total cyst size and weight of Nano-ABZ+MBZ had significantly lower total cyst numbers than the ABZ+MBZ. As well as the cyst with the maximum size and highest weight of Nano-capsule group had significantly lower than control groups. In conclusion, ABZ+MBZ-Nano-capsule can serve as suitable alternatives to chemical drugs. With the right application of nanotechnology, it is possible to possess the potential to produce safe and effective drugs, which has promising implications.

کلیدواژه ها:

Nanotechnology ، Nano capsule ، Hydatidosis ، Albendazole ، Mebendazole