CuFe₂O₄@SiO₂-EA: A Novel, Green, and Recyclable Nanomagnetic Catalyst for Synthesis of Pyrimido[۴,۵-𝑑] Pyrimidines Derivatives

In this study, a new magnetic nanoparticles functionalized with ethylamine (CuFe۲O۴@SiO۲-EA) was synthesized as a heterogeneous and recyclable catalyst. This catalyst was used in the synthesis of pyrimido[۴,۵-d]pyrimidine derivatives via one-pot three-component reaction of aromatic aldehydes, barbituric acid/thiobarbituric acid, and urea/thiourea in water solvent at ۸۰ °C. Techniques including scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), X-ray diffraction (XRD), transmission electron microscopy (TEM), vibrating sample magnetometry (VSM), and energy dispersive X-ray analysis (EDX) were used to elucidate the catalyst structure. Due to the magnetism of these nanocatalysts, they can be easily separated from the reaction medium using a simple magnet and used multiple times without significant reduction in catalytic activity.

کلیدواژه ها:

CuFe₂O₄@SiO₂-EA ، Pyrimido[۴ ، ۵-𝑑] pyrimidines ، Barbituric acid ، Urea