Association Between Coagulation Profiles and Platelet Count in Type ۲ Diabetes Mellitus Patients: Insights from a Study in Nepal

Type ۲ Diabetes Mellitus (T۲DM) presents a significant global health challenge, affecting metabolic processes and increasing cardiovascular risk. Elevated blood sugar levels in diabetes contribute to heightened clot formation and disrupt coagulation mechanisms, fostering atherosclerosis and altering platelet activity. This study aims to analyze the coagulation markers Prothrombin Time (PT), Partial Thromboplastin Time (PTT), and platelet counts in T۲DM patients, investigating the influence of elevated blood sugar levels on coagulation changes. Conducted at the Nepal Cardio Diabetes and Thyroid Centre, this cross-sectional observational study selected T۲DM-diagnosed patients as cases and healthy individuals as controls. Blood samples were analyzed using standard techniques, and statistical analysis was performed using the Statistical Package for the Social Sciences (SPSS) version ۲۱. Significant differences were observed in PT, International Normalized Ratio (INR), PTT, and platelet counts between the cases and controls, indicating altered coagulation pathways and reduced platelet counts in T۲DM patients. These findings suggest a hypercoagulable state in diabetic patients, contributing to atherogenesis.

کلیدواژه ها:

Prothrombin Time ، PTT ، INR ، Type ۲ Diabetes Mellitus ، SPSS