Risk factors, and antibiotic resistance pattern of Escherichia coli with extended-spectrum β-lactamase enzyme in west of Iran
محل انتشار: مجله فیزیولوژی پزشکی، دوره: 4، شماره: 1
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 91
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شناسه ملی سند علمی:
JR_JPHYS-4-1_006
تاریخ نمایه سازی: 1 اسفند 1403
چکیده مقاله:
Background: Extended-spectrum β-lactamases (ESBL) is present in drug-resistant enterobacteriaceae that is causing many epidemics in hospitals of developing countries; it remarkably limits therapeutic options and increases the rate of motility and morbidity. In order to choose the most appropriate treatment for urinary tract infections (UTI), it is necessary to know its risk factors. The aim of the present study is assessment of risk factors, and antibiotic resistance pattern of Escherichia coli (E. Coli) with ESBL (ESBL-EC) in the patients with UTI in west of Iran.Methods: This case-control study was conducted on patients with UTI referred to Sanandaj Tohid Hospital in Iran during March ۲۰۱۵ to March ۲۰۱۷, who had positive E. coli culture.they were divided into two groups of case (posetive ESBL-EC) and control (negative ESBL-EC) . Demographic data and risk factors findings were compared in the two groups. Using disk diffusion method. Antibiogram test was performed. SPSS software version ۲۱ was used to analyze the data and p ˂۰.۰۵ was considered as the significant level.Result: ۹۸ patients with UTI and positive E. coli cultures (۴۹ case and ۴۹ control) were evaluated . Risk of UTI induced ESBL-EC was increased ۳.۳۳ times in patients with urinary catheterization in the last ۱۲ months (OR = ۳.۳۳; ۹۵% CI: ۱.۳۳ – ۸.۳۵; p = ۰.۰۱۰). Conclusion: Based on the findings of this study, urinary catheterization in the last ۱۲ months increased the risk of UTI induced ESBL-EC and cotrimoxazole and ciprofloxacin should not be administered for treating E. coli-induced UTI in Sanandaj.