Alteration in some serum enzyme levels of rats during experimental infection with Toxoplasma gondii

Objective: The entry of Toxoplasma gondii into the bloodstream and other tissues (such as liver, muscle, cardiac muscle, …) of intermediate hosts and its multiplication in nucleated cells may cause changes in plasma levels of various enzymes due to tissue damage. In present study the serum levels of AST, ALT, ALK/P, CPK, LDH, and ACP in rats infected experimentally with Toxoplasma gondii have been investigated. Materials and Methods: Totally, ۱۱۶ uninfected rats were divided into ۸۷ as case group and ۲۹ as control group. The case group was infected intraperitoneally with ۵۰۰۰۰ tachyzoites. Blood specimens were taken from cases and its control once every ۸ hours in the first three days and then once every three days for a period of ۶۰ days and serum levels were measured for the mentioned enzymes. Results: During the study, the following changes were observed: AST in the first ۸ hours, from the ۳۲th hour till the ۴۰th hour and from the ۴۸th hour till the ۵۶th hour; ALT in the first ۸ hours and from the ۴۸th hour till the ۵۶th hour; ALK/P from the ۲۴th hour till the ۴۰th hour and from the ۴۸th hour till the ۶۴th hour; CPK and LDH from the ۲۴th hour till the ۴۰th hour and from the ۴۸th hour till ۵۶th hour; ACP from the ۱۶th hour till the ۴۸th hour. But afterward, whole offer mentioned enzyme shifted to normal levels. Conclusion: Alteration in serum enzyme levels of rats during infection with Toxoplasma gondii found is not permanent.

کلیدواژه ها:

Toxoplasma gondii ، Rat ، Serum enzyme ، توکسوپلاسما گوندیی ، رت ، آنزیم های سرمی