Histopathologic and biomechanical comparisons of the properties of skin, sutured with an Iranian and a foreign brand silk suture in rat

Purpose: Since there have been some debates about using Supa brand silk, this study was designed to elucidate the possible differences between Supa and Ethicon silk in suturing rat skin. Materials & Methods: This study was carried out on ۶۰ female Spragne-Dawly albino rats. The animals were randomly assigned to two equal groups. In group one, ۳/۰ silk, Supa product, and in group two, ۳/۰ silk Ethicon product were used. Following general anesthesia and surgical preparation, a ۵ cm midline abdominal skin incision was made and sutured by a simple interrupted pattern. Fifteen animlas of each group were sacrificed on day ۶ for the histopathologic examination and the rest of the animals, on day ۱۳ for histopathologic and biomechanical examinations. Histopathologic sections were stained by H&E and examined under the light microscope for the re-epithelialization, acanthosis, age of granulation tissue, dermatitis, hyperemia, and presence of giant cells. Results: There was no significant differences between the two groups on day ۶ and ۱۳ (P>۰.۰۵). In the biomechanical study, the following parameters were measured from load-elongation curves: the ultimate strength, ultimate strain, yield strain, stiffness, and maximum stored energy. Regarding these factors, there was no significant differences between the groups either (P>۰.۰۵). Conclusion: According to the results of this study and considering the price and availability, using Supa silk can be recommended with confidence and reliability.

کلیدواژه ها:

Supa silk ، Ethicon silk ، Histopathology ، Biomechanics ، Rat Skin ، بیومکانیک ، نخ سیلک سوپا ، نخ سیلک اتیکون ، هیستواپتولوژی ، پوست موش صحرایی