Development and Characterization of aHydroxyapatite-Alumina-Silicon Carbide CompositeScaffold for Bone Tissue Engineering

Bone fractures and defects pose significant challenges in clinical treatment, often requiring innovative approaches for effective repair and regeneration. This study explores the fabrication and characterization of a hydroxyapatite-alumina-silicon carbide (HA-Al O -SiC) composite scaffold for bone tissue engineering applications. The scaffold was prepared using a foam impregnation method with hydroxyapatite, alumina, and silicon carbide powders, followed by sintering at high temperatures to achieve a porous structure and mechanical stability. Scanning electron microscopy (SEM) revealed a highly porous architecture with interconnected micropores and uniform grain morphology, with grain sizes ranging from ۲.۵ to ۵ μm. Bioactivity was confirmed through hydroxyapatite layer formation after immersion in simulated body fluid (SBF).Cell culture studies with Saos-۲ osteoblast-like cells demonstrated biocompatibility, with growth curves showing a comparable population doubling time of ۴۰ ± ۰.۲۳ hours for cells cultured on scaffolds and standard tissue culture surfaces. The scaffold’s mechanical robustness, bioactivity, and support for cellular processes highlight its potential for applications in bone repair and regeneration. These findings suggest that the HA-Al O -SiC composite scaffold is a promising candidate for orthopedic and dental implants, addressing critical challenges in bone tissue engineering

کلیدواژه ها:

Hydroxyapatite ، Alumina ، Silicon carbide ، Composite scaffold ، Bone tissue engineering ، Bioactivity