Association of Lung CT-scans and Laboratory Findings with Disease Outcomes in COVID-۱۹ Patients

سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 109

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شناسه ملی سند علمی:

JR_RCM-11-3_006

تاریخ نمایه سازی: 14 بهمن 1403

چکیده مقاله:

Introduction: The COVID-۱۹ pandemic has underscored the necessity of investigating the relationship between radiological and laboratory findings with disease outcome in COVID-۱۹ patients. This study aimed to explore the association between CT-scan finding and laboratory results with disease outcome, including recovery without complications, ICU admission, or mortality.Methods: This retrospective cross-sectional study analyzed medical records and laboratory data from COVID-۱۹ patients at our institution from September ۲۰۲۰ onwards. All demographic, laboratory findings, as well as CT-scan data such as ground-glass opacity, consolidation, pleural effusion, cardiomegaly, mediastinal lymphadenopathy, and pulmonary involvement score at admission were collected. Patients were categorized based on outcome status and compared for all study variables. Results: Significance differences were observed for CT-score values between deceased patients and those who recovered (P<۰.۰۰۱), indicating a more severe lung changes in patients who died due to COVID-۱۹. Additionally ICU-admitted patients had higher likelihood of underlying comorbidities and elevated CT-score levels. Laboratory markers such as ESR, Ferritin, LDH, Neutrophil count, and RDW were significantly higher in patients requiring ICU admission (P<۰.۰۵). Deceased patients were more likely to have underlying diseases, ground glass opacity, cardiomegaly, and higher CT-scores. Laboratory markers such as ESR, CRP, Ferritin, LDH, and others were also significantly higher in expired patients.Conclusion: There was a strong association between laboratory and CT-scan findings with disease outcomes in COVID-۱۹ patients. The combination of laboratory markers and CT-scan findings can serve as robust predictors of disease outcomes. Further studies are needed to validate these findings in larger cohorts.

نویسندگان

Sahar Ravanshad

Department of internal medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Marieh Alizadeh

Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Aida Bakhshi

Clinical Research development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

Sepideh Hejazi

Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Mina AkbariRad

Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Hassan Mehrad-Majd

Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran