Ki-۶۷: A Prognostic Parameter in Breast Cancer with Prostate Metastatic Patient

Background: Ki-۶۷, a nuclear protein linked to cellular proliferation, is a critical biomarker in breast cancer prognosis. However, its role in breast cancer metastasis to the prostate remains underexplored due to the rarity of this condition. This study investigates the prognostic significance of Ki-۶۷ in breast cancer patients with prostate metastasis.Materials and methods: A retrospective cohort analysis was conducted on ۵۰ breast cancer patients with prostate metastasis, identified from a tertiary care center's cancer registry (۲۰۱۰-۲۰۲۰). Ki-۶۷ expression was assessed via immunohistochemistry and categorized into low (<۱۵%), intermediate (۱۵-۳۰%), and high (>۳۰%) groups. Overall survival (OS) was analyzed using Kaplan-Meier curves and Cox proportional hazards models, adjusting for age, tumor grade, and hormone receptor status.Results: The median OS was ۲۴ months. High Ki-۶۷ levels were significantly associated with poorer OS (۱۲ months) compared to intermediate (۲۴ months) and low (۳۶ months) levels (p<۰.۰۰۱). Multivariate analysis confirmed high Ki-۶۷ as an independent predictor of poor OS (HR ۲.۵, p=۰.۰۰۲).Conclusion: Ki-۶۷ is a significant prognostic marker in breast cancer patients with prostate metastasis, with high levels indicating worse outcomes. These findings highlight the importance of Ki-۶۷ in guiding prognosis and treatment in this rare metastatic presentation.

کلیدواژه ها:

Ki-۶۷ ، breast cancer ، prostate Metastasis ، Prognosis ، Overall survival