Application of biodegradable polymeric composites in cartilage tissue regeneration using the electrospinning approach

Cartilage tissue, despite its critical role in joint function and structural support of the skeletal system, presents significant challenges in treatment due to its limited self-repair capacity and complex architecture. Conventional approaches, such as autologous and allogeneic transplantation, face inherent limitations, which leads to increased attention on tissue engineering using biodegradable composites as a desirable alternative. In this context, the electrospinning technique has emerged as an efficient and cost-effective method for producing nanofibrous composite scaffolds that mimic the structure of the natural extracellular matrix (ECM) of cartilage. These composite scaffolds, combining natural and synthetic polymers with reinforcing materials or additives, provide a conducive environment for the growth and proliferation of chondrocytes or mesenchymal stem cells, facilitating cartilage tissue regeneration. The use of various composite formulations, combined with process parameter optimization and enhanced cell-scaffold interactions, holds potential for the development of scaffolds with superior mechanical, biological, and structural properties, tailored for cartilage repair applications.

کلیدواژه ها:

Electrospinning ، Polymeric Composites ، Cartilage Tissue ، Biodegradable Scaffold