Effects Of Gallic Acid On ECG Parameters In Diabetic Male Rats Induced With Streptozotocin-Nicotinamide

This study aims to evaluate the effects of gallic acid on specific electrocardiography (ECG) parameters in mice with type ۲ diabetes, a condition where gallic acid has demonstrated potential benefits, including lowering blood sugar, providing antioxidant protection, reducing inflammation, and preventing arrhythmias.The mice were divided into four groups: a control group, a group induced with type ۲ diabetes using ۱۰۰ mg/kg nicotine amide and ۵۵ mg/kg streptozotocin, a diabetic group treated with ۱۵ mg/kg gallic acid for ۱۰ weeks, and another treated with the same dosage for ۳ weeks. Blood sugar levels were measured using the Accu-Chek device one-day post-final injection. Ketamine and anesthetic agents were then administered, and ECG readings were recorded. The hearts were later extracted and preserved. Data analysis was performed with SPSS using one-way variance analysis and the Duncan test at a significance level of P≤۰.۰۵.After ۱۰ weeks, significant improvements were observed in diabetic mice treated with gallic acid, including reductions in average blood sugar, glycosylated hemoglobin, malondialdehyde, LDL, VLDL, triglycerides, and cholesterol, alongside improved total antioxidant capacity and heart weight. However, the QRS interval and R-wave height in the ECG remained unchanged. The results underscore gallic acid’s antioxidant, antihyperlipidemic, and antidiabetic properties, highlighting its ability to protect the heart from diabetes-induced cardiovascular complications and support healthier physiological outcomes.

کلیدواژه ها:

Gallic acid ، Type ۲ diabetes ، Cardiovascular protection ، Electrocardiography (ECG) ، Antioxidant property