Impacts of Trace Elements and Antioxidant Vitamins on Anxiety-Depression Disorders in Children on Dialysis

Background & Objective: Few studies have compared the concentration of trace elements and antioxidants in the serum of depressed and non-depressed as well as children on dialysis with and without anxiety.  Materials & Methods:  A prospective cross-sectional research was conducted. Forty children undergoing dialysis were assessed to define the correlation between mean serum levels of Selenium, Zinc, Copper, Manganese, vitamin C, and vitamin E and their deficient levels with mood disorders. The Child Depression Inventory (CDI) and Depression Anxiety Stress Scale (DASS) scorings were applied. According to Scorings, patients were divided into no depression and depression and no anxiety and anxiety disorders groups. Results: Eighteen hemodialysis and ۲۲ peritoneal dialysis patients were enrolled. The median of age was ۱۱ years. Twenty-two patients (۵۵%) were males. Selenium, copper, and vitamin C deficiencies were found in ۳۲.۵%, ۱۵%, and ۲.۵% of patients, respectively. Anxiety and depression disorders were diagnosed in ۸۲.۵% and ۶۷.۵% of patients, respectively. No relationship between gender, modality of dialysis, duration from onset of dialysis, serum levels of hemoglobin, blood urea nitrogen, albumin, Zinc, Copper, Selenium, manganese, and vitamin C with anxiety and depression disorders (p > ۰.۰۵ for all). The severity of depression was higher in hemodialysis versus peritoneal dialysis patients (P < ۰.۰۰۱). The Serum level of Vitamin E significantly was higher in depressed in comparison with non-depressed cases (P=۰.۰۲). Conclusion: There was no relationship between trace elements and vitamin C serum level and depression or anxiety disorders. An unreported finding was significantly higher level of vitamin E in depressed patients in comparison to those without it.

کلیدواژه ها:

Dialysis ، Child ، Trace elements ، Depression ، Anxiety