Synthesis and Spectroscopic Characterization of Novel Amics and Cyclic Imides Derivatives of Bisphosphonic Acid

This study presents the synthesis and spectroscopic characterization of new amic and imide derivatives incorporating bis (phosphonic acid) moieties. The key starting material, [(۴-aminophenyl) (hydroxyl)methylene] bis (phosphonic acid) (۱), was reacted with various cyclic anhydrides-succinic, maleic, ۱,۸-naphthalic, ۳-nitrophthalic, glutaric, cis-۱,۳,۴,۶-tetrahydrophthalic, and pyromellitic dianhydride (۲)-to yield the corresponding amic acids (۳a–۳f and ۵g). These amic acids were subsequently dehydrated using acetic anhydride in the presence of anhydrous sodium acetate under reflux, producing novel imide derivatives (۴a–۴f and ۶g). The synthesized compounds were characterized through various physical and spectroscopic techniques, including Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (۱H, ۱۳C and ۳۱P NMR).

کلیدواژه ها:

Dronic acid ، Amic acids ، Imide ، Bisphosphonic Acid