Bibliometric Analysis and Content Review of Current Perspective on Heart Failure with Mildly Reduced Ejection Fraction Therapy

Heart failure (HF) becomes multifaceted cardiovascular disease that affects the universal health burden. Treatments of mildly reduced ejection fraction heart failure (HFmrEF) as one of the HF categories are still in the grey area. This study aims to analyse the trends and bibliometric data, also to understand the HFmrEF therapy by content review. Bibliometric information was collected from Scopus Database. The bibliometric data were analysed using R-package bibliometrix and its web-interface biblioshiny was also visualized using VOSviewer. A total of ۲۰۶ publications from ۲۰۱۶ to ۲۰۲۴ in heart failure therapy, HFmrEF was mostly discussed in ۲۰۲۳.  From the top ۱۰ of global cited documents, only ۳ documents discussed specifically about HFmrEF. Based on keyword analysis, HFmrEF were linked to HF therapies, including angiotensin receptor-neprilysin inhibitor (ARNi), angiotensin converting enzyme inhibitor (ACEi), angiotensin receptor blocker (ARB), beta-blocker (BB), mineralocorticoid receptor antagonist (MRA), and sodium-glucose cotransporter-۲ (SGLT۲) inhibitor, which are the four pillars of reduced ejection fraction heart failure (HFrEF) therapy. There is an upward-stable trend of HF publications from ۲۰۱۶ to ۲۰۲۳, including those for HFmrEF which is the most discussed topic in ۲۰۲۳. In terms of HFmrEF therapy, the four pillars of HF therapy are related to HFmrEF based on visualization analysis, although those medications are currently recommended only for HFrEF. HFmrEF therapy is still an interesting issue for upcoming research due to limited established positive trials.

کلیدواژه ها:

Bibliometric analysis ، Heart failure with mildly reduced ejection fraction ، therapy