Antinociceptive and anti-inflammatory activities of Ferula elaeochytris Korovin methanolic extract in rat model

Today, the current chemical agents for pain control have relatively many complications. They are associated with the occurrence of disorders in the digestive system, kidney damage, or addiction, which has caused people to find newer drugs that, in addition to removing side effects, are cheap and available. The present in vivo survey aimed to assess the antinociceptive and anti-inflammatory activity of Ferula elaeochytris Korovin methanolic extract (FEME) in male Swiss mice. After obtaining the methanolic extract through the maceration process, the antinociceptive efficacy of FEME at doses of ۲۵ to ۱۰۰ mg/kg was assessed by the tail-flick, hot-plate, and formalin tests. In addition, anti-inflammatory evaluation was performed by the Carrageenan-induced paw edema model. We found that in the tail-flick and hot plate test, FEME mainly at the dose of ۱۰۰ mg/kg significantly reduced the latency time as well as better the time of the observance of licking or jumping in comparison with normal saline (P<۰.۰۰۱). We reported that FEME at ۵۰, and ۱۰۰ mg/kg considerably declined the pain behaviors in the acute and chronic phase in comparison with normal saline (p<۰.۰۰۱). FEME markedly (p < ۰.۰۵) declined paw edema in a dose- and time-dependent response, so a significant difference was observed in paw edema followed by treatment with FEME at ۵۰ and ۱۰۰ mg/kg (p<۰.۰۰۱). To conclude, this study reported the potent analgesic and inflammatory effects of F. elaeochytris methanolic extract to control peripheral and central pain. However, additional experiments are mandatory to clear the accurate mechanisms of action of this plant.

کلیدواژه ها:

analgesic ، inflammation ، Natural Products ، In vivo ، Pain