Effect of Beta Vulgaris and Laurus Nobitis on Lipid Profile and Kidney in Hyperuricemia Rat

Abstract Background: Hyperuricemia is considered the main cause of many chronic and metabolic diseases. Hyperuricemia causes hyperlipidemia, increased serum creatinine, hyperglycemia, and weight gain through different pathways and mechanisms. The aim of this study was to investigate the effect of Beta vulgaris and Laurus nobilis on reducing the risk of hyperuricemia in developing metabolic disorders and kidney damage in a rat model. Methods: Twenty-four adult male albino rats of about ۲۰۰–۲۲۰ g body weight and ۸–۱۲ weeks old were kept in the animal house. The hyperuricemia rats, model group were given oxonic acid (۲۵۰ mg/kg/bw). Treatment groups were administered either Beta vulgaris or Laurus nobilis after induced hyperuricemia. Histopathological examination of kidney tissue and biochemical tests were done for all groups of rats. Results: Except for HDL, all biochemical parameters, including cholesterol (۴۹.۰۰±۶.۴۸), triglyceride (۴۷.۲۵±۲.۲۲), LDL (۳۴.۵۰±۳.۱۱), uric acid (۴.۹۰±۰.۲۲), urea (۴۶.۰۰±۰.۸۲), creatinine (۰.۳۵±۰.۰۳), blood sugar (۱۹۳.۰۰±۱۱.۲۰), and weight gain (۷۷.۷۵±۲.۰۶), were significantly decreased in the rats administered Laurus nobilis and Beta vulgaris treatments compared to hyperuricemia model rat (P. value ≤۰.۰۱). Nephron structure in Beta vulgaris and Laurus nobilis rat was less damaged. Conclusion: This study found hyperuricemia induces kidney damage and several metabolic disorders such as dyslipidemia, hyperglycemia, increased serum creatinine and urea, and weight gain in model rats. Beta vulgaris and Laurus nobilis decrease the biochemical parameters, and ameliorate the histopathological effects of hyperuricemia, such as atrophy of glomeruli and hydropic changes in the epithelial lining of proximal convoluted tubules. Laurus nobilis physiologically has a greater effect on lipid profile, blood glucose, serum creatinine, weight, and urea compared to Beta vulgaris.

کلیدواژه ها:

Hyperuricemia ، Metabolic disorder ، beta vulgaris ، Laurus nobilis ، Kidney damage