Cell death classification: A new insight based on molecular mechanisms

Cells tend to disintegrate themselves or are forced to undergo such destructive processes in critical circumstances. This complex cellular function necessitates various mechanisms and molecular pathways in order to be executed. The very nature of cell death is essentially important and vital for maintaining homeostasis, thus any type of disturbing occurrence might lead to different sorts of diseases and dysfunctions. Cell death has various modalities and yet, every now and then, a new type of this elegant procedure gets to be discovered. The diversity of cell death compels the need for a universal organizing system in order to facilitate further studies, therapeutic strategies and the invention of new methods of research. Considering all that, we attempted to review most of the known cell death mechanisms and sort them all into one arranging system that operates under a simple but subtle decision-making (If \ Else) order as a sorting algorithm, in which it decides to place and sort an input data (a type of cell death) into its proper set, then a subset and finally a group of cell death. By proposing this algorithm, the authors hope it may solve the problems regarding newer and/or undiscovered types of cell death and facilitate research and therapeutic applications of cell death. The innovation of this classification is in its ordering for setting up a platform in line with the possibility of identifying newer types. This would make classifying easier and might help facilitating the selection of treatment strategies in the overall framework of the process and even it may lead to inventions of novel research methods. Regulated cell death is a set of extremely complex biomolecular machineries that ultimately leads to cell destruction. Some of these mechanisms are specialized only in sake of destruction of the cell, if some of these modalities pass through a certain point after their initiation, then the process seems irreversible and it will be impossible to save the cell from its destructive fate. This certainty indeed is why we decided to call it definite or direct cell death wherein cell is directly and definitely going to be demised or demolished.

کلیدواژه ها:

Cell death ، Classification ، Algorithm