Evaluation the surgical techniques and endocrine-reproductive outcomes of ovarian transposition prior to pelvic radiotherapy

Premature ovarian failure (POF) may arise as a consequence of radiotherapy administered for the treatment of various female oncologic conditions. Prior to radiotherapy, fertility preservation can be achieved through a surgical procedure known as ovarian transposition (OT). Our review aims to investigate the various surgical techniques employed for OT and evaluate their impact on endocrine and reproductive outcomes. Materials & Methods: A comprehensive search was conducted utilizing reputable databases including Ovid, Elsevier, PubMed, and Google Scholar. The search encompassed literature published from the year ۲۰۱۸ to ۲۰۲۴ and was not restricted by language. A total of ۲۲ articles were initially identified, and after thorough summarization and analysis, ۱۸ articles were deemed relevant and selected for inclusion. Results: Two primary types of OT have been utilized: lateral and internal. While internal OT was predominantly investigated in scholarly articles, external OT was used in approximately equal proportions for both gynecological and non-gynecological tumors. The studies revealed no significant correlation between two types OT concerning the preservation of endocrine function. However, the data indicate that internal OT is associated with a higher percentage of patients experiencing pregnancies compared to lateral, and this difference is statistically significant. Conclusion: The surgical method depends on the type of disease, but OT especially medial OT when conceivable is constructive of ovarian function preservation and reproductive outcomes.

کلیدواژه ها:

Premature ovarian failure ، fertility ، endocrine ، radiotherapy