Polycaprolactone/Barium Titanate ۳D-Printed Scaffolds:Enhancing Bone Regeneration through BiodegradablePiezoelectric Composite Structures-a Review

Piezoelectric bone scaffolds are a significant innovation in tissue engineering, combining structural support with electroactive stimulation to enhance bone regeneration. This review focuses on ۳D-printed scaffolds made from polycaprolactone (PCL) and high-loaded barium titanate (BaTiO ), which integrate the advantages of biodegradable polymers and bioactive ceramics. PCL offers favorable biodegradability and mechanical properties, while BaTiO provides superior mechanical strength and piezoelectric capabilities that stimulate critical cellular responses for bone healing. Advanced ۳D printing techniques enable the fabrication of complex geometries that mimic natural bone, improving mechanical and biological functionality. Additionally, these scaffolds generate therapeutic electrical fields in response to mechanical stress, facilitating tissue regeneration without external power sources. This review consolidates recent findings on the mechanical, biological, cytotoxic, piezoelectric, and chemical properties of PCL/BaTiO scaffolds, highlighting their potential in advancing bone repair strategies and outlining future research directions in regenerative medicine.

کلیدواژه ها:

Piezoelectric ، ۳D printing ، Bone scaffolds ، PCL (polycaprolactone) ، BaTiO۳ ، Additive Manufacturing