Polycaprolactone/Barium Titanate ۳D-Printed Scaffolds:Enhancing Bone Regeneration through BiodegradablePiezoelectric Composite Structures-a Review

سال انتشار: 1403
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 224

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شناسه ملی سند علمی:

IMES18_240

تاریخ نمایه سازی: 12 دی 1403

چکیده مقاله:

Piezoelectric bone scaffolds are a significant innovation in tissue engineering, combining structural support with electroactive stimulation to enhance bone regeneration. This review focuses on ۳D-printed scaffolds made from polycaprolactone (PCL) and high-loaded barium titanate (BaTiO ), which integrate the advantages of biodegradable polymers and bioactive ceramics. PCL offers favorable biodegradability and mechanical properties, while BaTiO provides superior mechanical strength and piezoelectric capabilities that stimulate critical cellular responses for bone healing. Advanced ۳D printing techniques enable the fabrication of complex geometries that mimic natural bone, improving mechanical and biological functionality. Additionally, these scaffolds generate therapeutic electrical fields in response to mechanical stress, facilitating tissue regeneration without external power sources. This review consolidates recent findings on the mechanical, biological, cytotoxic, piezoelectric, and chemical properties of PCL/BaTiO scaffolds, highlighting their potential in advancing bone repair strategies and outlining future research directions in regenerative medicine.

نویسندگان

Melika Mirghaffari

Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

Shahram Mahboubi Zadeh

Department of Biomedical Engineering, Medical Engineering and Biology Research Center, Science and ResearchBranch, Islamic Azad University, Tehran, Iran

Atefeh Shahbazi

Department of Photo Healing & Regeneration Medical laser research center Yara institute, ACECR Tehran, Iran

Parastoo Noroozi

Department of Biomaterials, Faculty of Interdisciplinary Science and Technologies, Tarbiat Modares University, ۱۴۱۱۵-۳۳۶, Tehran, Iran