Synthesis of Metal-Organic Framework-Coated MagneticNanoparticles for Therapeutic Applications

Integrating magnetic targeting with therapeutic methods in one platform is a promising strategy to improvethe effectiveness of cancer treatment. In this study, a novel nanocomposite (CFO@PDA@UiO) was fabricated by thegrowth of UiO-۶۶ on Polydopamine-coated CoFe۲O۴ nanoparticle for photothermal therapy (PTT). TheCFO@PDA@UiO nanoparticles with an average diameter of ۵۰ nm, have a saturation magnetization of ۱۲.۰۶ emu/g.The ability of synthesized nanoparticles to increase the medium temperature within the range of hyperthermia therapy(۴۱-۴۸ °C) demonstrates their photothermal conversion efficiency.

کلیدواژه ها:

Cancer therapy ، Cobalt ferrite ، Magnetic nanoparticles ، Photothermal therapy