Effect of Hydrogel Containing Herbal Extract of Arctium lappa root on Traumatic Burn Wound Healing in Rat under HIIT Exercise

Introduction: Traumas have always been one of the most significant types of injuries to the body, among which burn wounds are notable. The recent study was designed to investigate the characteristics of chitosan hydrogel and Burdock root extract, along with the effect of high-intensity interval training (HIIT) on burn wounds. Methods: chitosan hydrogel containing Burdock root extract was designed as a wound dressing. Additionally, a HIIT regimen was designed and implemented for the groups three weeks prior to the start of the study. Seventy-two male Wistar rats were randomly divided into four equal groups. All groups were evaluated on days ۷th, ۱۴th, and ۲۱st days after wound induction based on macroscopic and microscopic parameters. Results: The results of macroscopic evaluation indicated that the wound contraction percentage in the first and second weeks showed a statistically significant difference in the group receiving HIIT and hydrogel, compared to other groups. In the third week, although there was no difference between the groups received only HIIT, H۲, and H۳ which only received hydrogel, all three groups demonstrated a statistically significant difference compared to the control group. Regarding the microscopic evaluation, all three groups performed better than the control group in terms of angiogenesis, re-epithelialization, inflammatory cells, collagen deposition, and fibroplasia, with slight differences among them. Among these groups, H۲ showed superior performance in all parameters compared to other groups. Conclusion: The recent study demonstrated that HIIT prior to wounding and the use of chitosan hydrogel containing Burdock root extract as a wound dressing, each individually, and positively influenced wound contraction and improved pathological wound healing factors. Additionally, the combined approach of HIIT and the use of this hydrogel can enhance the effects of each one on wound healing and rehabilitation.

کلیدواژه ها:

traumas ، wound dressing ، HIIT ، Chitosan ، burdock