Evaluating Desmopressin Spray for Surgical Wound Drainage in Femoral Surgery Patients in Taleghani Hospital

Introduction: Prolonged wound drainage (PWD) increases the risk of infection by compromising the skin barrier and promoting bacterial growth. Desmopressin, known for its hemostatic properties, has demonstrated the potential to reduce bleeding and accelerate wound healing in various surgical procedures.Methods: In study, ۵۰ patients aged between ۱۸ and ۶۵ undergoing total joint arthroplasty and any femoral fractures were divided into intervention and control groups. Desmopressin spray with a daily dose of ۸۰ micrograms for two days was prescribed for the intervention group. Wound discharge volume, hospitalization, and postoperative complications were compared between the two groups.Results: There was a notable reduction (P=۰.۰۱۶) in discharge volume observed within both the control (۱۴.۴ ± ۱۴.۳ milliliters) and desmopressin-administered (۶.۵ ± ۷.۸ milliliters) groups on the second day postoperative. Also, discharge volume decreased significantly in both groups (p<۰.۰۰۱), and a significant discrepancy emerged in the efficacy of discharge reduction between the two groups (p<۰.۰۰۱). However, hospitalization was significantly (P=۰.۰۰۸) lower in the intervention group (۳.۶۴ ± ۲.۵۱ days) than in the control group (۶.۳۶ ± ۳.۱ days).Conclusion: Patients receiving desmopressin exhibited significantly reduced discharge and shorter hospitalization periods than controls.

کلیدواژه ها:

Desmopressin ، Prolonged Wound Drainage ، Femoral fractures ، Total Joint Arthroplasty