Voltammetric sensor for Nifedipine at woolen ball-shaped nanostructure modified glassy carbon electrode

This work faces this challenge by the development of a novel electrochemical sensor via modifying a glassy carbon electrode (GCE) with woolen ball-shaped La۳+/TiO۲ nanostructure (WB-S La۳+/TiO۲-NS) for the detection of Nifedipine (NFP). Different characterization techniques indicate the successful synthesis of desired composite materials. Modified electrode exhibited higher peak current than the bare GCE, with excellent electrocatalytic ability to oxidize NFP, due to its higher conductivity, catalytic effect and synergistic effects between La۳+ and TiO۲ nanostructure. Under optimized condition, differential pulse voltammograms (DPV) demonstrate that the oxidation peak current was proportional to its concentration in the range of ۰.۰۰۱–۵۰۰.۰ µM (R۲ = ۰.۹۹۹۷) and low detection limit (۰.۴۳ nM). In addition, the modified electrode affirms good stability and reproducibility, making it simple, cost effective with high sensitivity. The results confirmed that making a composite is a key strategy for improving the physicochemical properties of TiO۲ nanostructure and that modifying electrode surfaces with novel composites can enhance the detection of NFP.

کلیدواژه ها:

Nifedipine ، Voltammetry ، Lanthanum ، nanostructure ، Titanium dioxide