Effects of trona (sodium sesquicarbonate) on physio-biochemical profiles and cardiovascular risk indices in Wistar rats

Purpose of the study: This investigation aimed to assess the impact of trona on the cardiovascular risk markers and physio-biochemical profiles of rats administered graded dosages over ۲۸ days. Five groups (n = ۵) of rats—A, B, C, D, and E—were randomly assigned, with E acting as the control. For ۲۸ days, rats in groups A, B, C, and D were administered trona at doses of ۵۰, ۱۰۰, ۲۰۰, and ۴۰۰ mg/kg, correspondingly. All over the investigation, distilled water was provided to the animals in the control group. We measured body weights, oxidative stress, hematology, hepatorenal profiles, somatic organs, fasting blood glucose (FBG) levels, and cardiovascular risk indices (CVRI). Findings: Rats administered ۴۰۰ mg/kg had higher FBG levels (p < ۰.۰۵) than the control group. Group D showed decreases (p < ۰.۰۵) in erythrocytic indices, total protein level, and heart-body index with concurrent increases (p < ۰.۰۵) in total leucocyte counts (TLC) and creatinine levels in comparison to the control group. Rats in groups B, C, and D showed higher levels of catalase activity (p < ۰.۰۵) compared to the control group. Rats given ۱۰۰ mg/kg or above of trona showed increases (p < ۰.۰۵) in CVRI compared to controls. Conclusions: There were dose-dependent harmful effects on the erythrocytic indices, high exposure to T۲DM (type-۲ diabetes mellitus), and increased CVRI levels in rats dosed orally with ≥۱۰۰ mg/kg trona for ۲۸ days.

کلیدواژه ها:

Cardiovascular indices ، hepatorenal profiles ، oxidative stress ، Rats ، trona