Investigating The Molecular Link Of Salvia Plant Compounds On The Inhibition Of Alpha-Amylase Enzyme In The Treatment Of Diabetes

Background and purpose: Diabetes is a key public health issue due to its expanding worldwide disease burden, which is placing unsustainable demands on people with the condition, their caregivers, health systems, and society at large. This study aims to investigate the bioinformatic effects of salvia plant compounds in inhibiting alpha-amylase enzyme, which is a key enzyme in diabetes, in order to take an effective step in its treatment.Methods: In this study, Discovery Studio, Chimera, Hyperchem and Hdock online server software were used to investigate how the compound binds to the active site of the enzyme, draw the chemical structure of compounds, optimize energy, study docking and final analysis. became.Findings: The studied compounds are able to occupy the active site of the enzyme, and the binding energy level in Rosmarinic acid was -۱۹۵.۴۶, Luteolin -۱۸۰.۳۴, Genkwanin -۱۶۸.۲۸ and caffeic acid -۱۲۵.۵۷.Conclusion: Considering the relatively high effectiveness of the compounds in the bioinformatics study, the effects of these compounds can be analyzed in vitro and in vivo for additional investigations.

کلیدواژه ها:

Diabetes ، molecular docking ، alpha-amylase ، inhibitory compounds