Clinicopathological Implications of Serum level of IL-۲۷ in Endometrial Cancer Patients

Background & Objective: Endometrial cancer (EC) is the most prevalent gynecological malignancy in more developed countries. Multiple researches have been done about the role of IL-۲۷ in different cancers that suggest a dual role for this cytokine. In the present study, we evaluated the serum level of IL-۲۷ in endometrial cancer patients. We also investigated the correlations between serum levels of IL-۲۷ and the demographic and clinicopathologic features of the patients.Materials & Methods: In this case-control study, ۶۵ endometrial cancer patients and ۵۸ sex-age-match healthy controls were investigated. Serum levels of IL-۲۷ in both cases and the control group were assessed by a reliable and specific sandwich enzyme-linked immunosorbent assay (ELISA) kit and results were analyzed with SPSS.Results: We observed that the serum level of IL-۲۷ in EC patients was dramatically higher than in the control group (P=۰.۰۰۳). Additionally, Higher grades of EC (grade II and III) showed higher IL-۲۷ serum levels compared to the control (P=۰.۰۰۶ and P=۰.۰۱ respectively). No significant correlations between serum levels of IL-۲۷ and lymph node involvement, tumor stage, tumor size, and demographic features of the patients were detected.Conclusion: Our results showed that there is a statistically significant difference between serum levels of IL-۲۷ in EC patients and controls. Therefore, the serum level of IL-۲۷ may exert a role in the pathogenesis of endometrial carcinoma, although further studies are needed.

کلیدواژه ها:

Cytokines ، Endometrial Cancer ، Gynecological Malignancy ، IL-۲۷