The Efficacy and Safety of Green-Lipped Mussel Extract Plus Ginkgo Biloba on Anti-Inflammatory Status in Patients with Knee Osteoarthritis

سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 80

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شناسه ملی سند علمی:

JR_JNFS-9-4_009

تاریخ نمایه سازی: 28 آبان 1403

چکیده مقاله:

Clinical research on the efficacy of nutraceutical compounds recommended for the relief of osteoarthritis (OA) symptoms has been largely disputed. In addition, no link has been established between its safety and efficacy in Kurdish population. The aim of this study is to determine the efficacy of New Zealand green-lipped mussel extract + Ginkgo biloba (GLME+) in patients with OA, and analyze the effect of GLME+ on inflammation. Methods: In an open-label, single-group allocation study, ۴۰ patients diagnosed with knee OA were administrated ۱۰۰۰ mg/day of New Zealand green-lipped mussel extract and ۱۰۰ mg/day of Ginkgo biloba for eight weeks. The outcome measure was scored using Western Ontario and McMaster Universities arthritis index (WOMAC). The serum concentration of inflammatory chemokine (CCL۳) and myeloperoxidase (MPO) were measured. An intention-to-treat analysis was employed and subject data at T۰ and T۸ weeks. Results: Results showed a significant improvement in WOMAC score in post-treated OA patients with GLME+ (P<۰.۰۰۱). In addition, CCL۳ serum levels were significantly decreased after an ۸-week intervention (P<۰.۰۰۱). Moreover, no statistical significance was observed within groups in MPO serum levels (P> ۰.۰۵). Conclusions: GLME+ improved knee joint pain, stiffness, and mobility in OA patients. Two of GLME+'s chondroprotective properties were the reduction of oxidative damage and the inhibition of inflammation, both of which have been linked to the etiology of OA cartilage destruction. The findings indicated that GLME+ may be useful in the treatment of OA patients.

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نویسندگان

Shukur Wasman Smail

College of Pharmacy, Cihan University-Erbil, Kurdistan Region, Iraq

Mahdi Khaled Qadir

Department of Physiotherapy, Erbil Technical Health and Medical College, Erbil Polytechnic University, Erbil, Iraq

Omer Ahmed Hamad Amin

Department of Rheumatology, Ranya Teaching Hospital, Ministry of Health, Ranya, Kurdistan Region, Iraq

Dedawan Rasul

Kurdistan higher council of medical specialties, Erbil, Kurdistan Region, Iraq

Sonia Elia Ishaq

College of Pharmacy, Cihan University-Erbil, Kurdistan Region, Iraq

Zhikal Omar khudhur

Biology Education Department, Tishk International University, Erbil, Iraq

Mohammed Ibrahim Mohialdeen Gubari

Community Medicine, College of Medicine, University of Sulaimani, Sulaimani, Iraq

Kurosh Djafarian

Department of Clinical Nutrition, School of Nutrition and Dietetics, Tehran University of Medical Science, Tehran, Iran

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