Relationship between Diet-Related Inflammation and Hospitalization Risk and Disease Severity in Patients with COVID-۱۹

Increased serum concentrations of inflammatory biomarkers in patients indicate a strong association between COVID-۱۹ and inflammation. However, the association between diet-related inflammation and COVID-۱۹ has been less investigated. The aim of this study is to investigate whether the inflammatory scores of the diet are associated with the severity of COVID-۱۹ disease and the probability of hospitalization of patients.  Methods: The authors conducted a cross-sectional study involving ۱۴۱ patients with COVID-۱۹. The empirical dietary inflammatory pattern (EDIP) and dietary inflammation scores (DIS) were calculated based on a ۱۴۷-item semi-quantitative food frequency questionnaire. The association between serum levels of inflammatory biomarkers and diet-related inflammation was also investigated. Results: ۷۴ inpatients and ۸۷ outpatients participated in this study. Higher DIS scores were significantly associated with an increased risk of COVID-related hospitalization (Tertile۳ vs. tertile۱: OR = ۳·۶۲; ۹۵ % CI ۱·۴۳ to ۹·۱۴, P=۰·۰۰۸ after fully adjustment). This association with EDIP was also observed, but it was not significant. Conclusion: The data from this provide evidence that a pro-inflammatory diet was associated with higher risk of hospitalization due to high severity of COVID-۱۹

کلیدواژه ها:

COVID-۱۹ ، Inflammation ، Diet ، Infections ، Biomarkers.