Highly sensitive determination of nimesulide using Glassy Carbon Electrode Enhanced Graphene Oxide-Multi-walled Carbon Nanotubes

Methods: NIM was determined utilizing (GO-MWCNTs/GCE) using DPV. The impact of different experimental factors, such as scan rate, pH, and aggregation time, on the voltammetric responses of NIM was assessed.Results: NIM achieved an irreversible electrochemical reaction controlled by the diffusion-controlled electrode method at GO-MWCNTS/GCE. This research examined the relationship between peak oxidation current and concentration under optimal conditions. A calibration curve was plotted showing the linear range of ۰.۰۶-۰.۸ ppm and limited of detection of ۰.۰۰۰۳۱۸ ppm. The approach was effectively used to detect NIM in drugs as well as in human serum and urine samples. Results refer that the chosen method is fast, responsive, and cost-effective. The sensor (GO-MWCNTs/GCE) had an excellent reproducibility and good repeatability.

کلیدواژه ها:

Nimesulide ، GO-MWCNTs ، glassy carbon electrode ، CV ، DPV