Recent advances in the synthesis of trifluoromethyl ethers through the direct O-trifluoromethylation of alcohols

Abstract: In this review, the pivotal achievements and recent advances on direct O- trifluoromethylation of alcohols reported up to ۲۰۲۴ are retrospectively considered and their potency for synthesis of useful trifluoromethyl ethers is demonstrated. The reported data are organized according to main types of catalytic systems (i.e., metal-catalyzed/mediated, electro-catalyzed, base-mediated, and catalyst-free O-trifluoromethylations).

کلیدواژه ها:

organofluorine compounds ، trifluoromethyl ethers ، oxidative O-functionalization ، trifluoromethylation ، Alcohols