Nanoscale Covalent Organic Frameworks in Modern Cancer Therapy

Covalent organic frameworks (COFs) are innovative crystalline porous materials that have garnered significant interest due to their intricate structures and unique characteristics, such as combinability, crystallinity, porosity, stability, flexibility, and biocompatibility. Initially, COFs found utility in industrial sectors, serving functions as adsorbents, separation agents, sensors, and catalysts. However, recent investigations have shifted focus to their potential biomedical applications.The substantial porosity inherent in COFs facilitates the efficient incorporation of a variety of imaging and therapeutic agents. In some instances, these frameworks can be utilized to deliver therapeutic drugs and functional groups through covalent linkages. Additionally, the organic components of COFs can be altered after synthesis to establish specific interactions with biomarkers. These remarkable properties position COFs as promising nanocarriers for bioimaging and therapeutic uses.Despite nearly a decade of intensive research aimed at the rational design and synthesis of organic covalent frameworks, their therapeutic applications at the nanoscale remain largely underexplored. This article examines recent progress in the application of drug-containing organic covalent frameworks for cancer treatment, highlighting various strategies such as drug delivery, photodynamic therapy, and photothermal therapy

کلیدواژه ها:

“Covalent Organic Frameworks ، Cancer ، Nano Sclale ، Drug Delivery ، Photothermal Therapy ، Photodynamic Therapy”