Evaluation the Effect of Supplements Containing Vitamin D and Trace Elements in Patients with Moderate to Severe Asthma

Background: Asthma is a common and major allergic disease in the world. We aimed to investigate the impact of supplements with vitamin D, folic acid, selenium, zinc, and copper in patients with moderate to severe asthma. Method: In this clinical trial study ۷۰ patients above six years old with moderate to severe asthma, were divided into two groups, randomly; one group received daily Asmavit syrup, ۱۰ ml (Asmavit, Vitabiotics Ltd, London, UK), and the other group received daily ۱۰۰۰ IU vitamin D۳ drops (Asmavit, Vitabiotics Ltd, London, UK) for two months along with ordinary treatment for asthma. Clinical and physical examinations, immunological and biochemical tests were carried out for each patient before and after the treatment. Results: The mean age of patients was ۳۹.۹± ۱۴.۷ years old, and the mean disease duration was ۸.۸ ± ۹.۸ years. A significant increase in lung function, asthma control, and quality of life score tests was observed in both groups after the treatment (P< ۰.۰۵). There was no significant difference in cytokines expression levels before and after the treatment with vitamin D۳ or Asmavit (P> ۰.۰۵). Serum levels of selenium and folic acid before treatment were correlated with disease severity, while post-treatment vitamin D levels significantly increased FEV۱ (P> ۰.۰۵). Oxidative stress levels reduced in both groups, with greater reduction in the vitamin D group (P< ۰.۰۵). Conclusion: Supplements, particularly vitamin D, when combined with standard asthma treatment, may effectively improve clinical symptoms and enhance the quality of life for asthmatic patients.

کلیدواژه ها:

Asthma ، Vitamin D ، Supplements ، Oxidative stress.