and fertility rises a lot of hope for birth of healthy children andprevention of congenital malformations. Genetics plays an importantrole in this regard, but collaboration and interconnectionbetween obstetrician/gynecologists, perinatalogists, midwiferies/nurses, geneticists and consultants is very important.Responsibility of these groups will start from decision of couplesto conceive or even before marriage. The role of obstetrician/gynecologists as the first who visit couples and midwiferies/nurses or general physicians in an optimal patient referringsystem, are most important. Suitable referring protocols andguidelines can avoid from unnecessary tests, which lead tomore costs and more anxiety for couples.Genetic diseases in the couples’ relatives, make carrier testingthrough regular methods necessary. Alternatively, expandedcarrier screening like exome sequencing, even reveal thoselate onset diseases that offspring may encounter in elderly age,which is a challenging issue.Genetic work up of infertile patients is very important. Treatmentteam and especially genetic consultants must check geneticcauses of infertility. Cases such as male infertility due tosever decrease or absence of spermatogenesis, recurrent implantationfailures and recurrent abortions in this group of patients,must be noticed intensely.Perinatal tests in the late first trimester or early in second trimesterare so much important. How to select the tests such asmaternal serum markers, sonography, cell free DNA present inmaternal blood and the more invasive tests like Chorionic villussampling (CVS) or amniocentesis is important duty of perinatalogists.Does any of these tests are obsoleted? On the otherhand, doing old procedure with new facilities like microarrayfor amniocentesis, does it provide information that is more precise?Are cfDNA test results definite?What is the role of genetic consultants, nursing/midwifery inpre- and post-test counseling to increase the couples’ ability tomake informed decisions and reduce their anxiety? When thereis need for intervention of psychologists?Whether preimplantation genetic screening (PGS) has anyrole in achievement of infertile patients to a healthy birth, isyet under discussion among specialists. In the recent years,great developments take place in the procedure of PGS. Thesechanges were made in whole chromosomes study and in thebiopsy method. Are these changes improve the diagnostic valueof PGS? Or extra data such as RNA sequences must be addedto them?The role of preimplantation diagnosis (PGD) in cases who coupleis carrier of genetic defects is obvious, but the implantationof healthy embryos, is very important. Do these proceduresmove toward more comprehensive and precise methods?The above issues and challenges especially those in the mind ofaudiences will be discussed in the panel.