Mechanisms Involved in Oocyte Maturation and Embryo Development in PCOS: Bioinformatics Analysis

Background: Polycystic ovary syndrome (PCOS), an multifactorialendocrine disorder that involved ۵-۱۰% of reproductiveage women and responsible for ۷۵% of lack ovulation infertility.The prevalence of syndrome is more than ۶% in Iran. Therisk of miscarriage in early pregnancy and premature birth increasedin women with polycystic ovary syndrome. This studywe investigate mechanisms involved in polycystic ovary syndrome.Materials and Methods: By studying numerous articles wereextracted about ۴۴۷ (up-regulated or down-regulated) proteinsthat were significantly involved in polycystic ovary syndrome.For network construction and its analysis use Cytoscape saftware.Gene ontology analysis for whole proteins was performedon Bingo Cytoscape app.Results: SIRT۱ is known proteins that showed high degreeamong the ۴۴۷ proteins that were involved in mechanisms ofPCOS. This protein is a NAD-dependent protein deacetylasesirtuin-۱. The most significant proteins obtained of gene ontologywere showed roles in protein folding, cell aging, tricarboxyliccycle, glycolysis and metabolic process in PCOS.Conclusion: SIRT۱ is a NAD-dependent protein deacetylasesirtuin-۱ that can modulate chromatin function through deacetylationof histones and can promote alterations in the methylationof histones and DNA, leading to transcriptional repression.Glycolysis and tricarboxylic cycle are pathways associatedwith glucose metabolism, disturbances in these pathways causediabetes in women with polycystic ovary syndrome. MDH۱,SOD۱, SOD۲ and PHB۲ proteins plays a role in ovary aging.Thses pathways prevent oocyte maturation in pcos women andcause infertility in this group of women. Therefore, recognizingthese molecules can be effective in improving fertility in PCOSwomen.

کلیدواژه ها:

PCOS ، Proteomic ، Oocyte Maturation ، Gene Ontology