Paternal Lifestyle: How Bad (Harmful) Are Trans Fatty Acids for Sperm Quality of Male Offspring

Background: It has been demonstrated that paternal diet caneffect on the metabolic status of the offspring. In the currentstudy we tried to investigate the influence of paternal trans fattyacids diet on sperm quality of rat offspring. For this respect, ۲۰adult male Wistar rats (۵ in each groups) were included to thestudy which their fathers were fed for ۶۰ days in the following four diet groups: (C) control diet (CT) control diet with transfatty acid (E) a diet containing vitamin E and (ET) a diet containingvitamin E and trans fatty acid.Materials and Methods: Epididymal tissues were collectedfrom male offspring rats to analyze sperm parameters by usingCASA computer analysis. Data were statistically analyzed usingone-way ANOVA.Results: There were significant differences in concentration,progressive and total motility of sperm parameters amonggroups. Accordingly to Duncan's test, sperm concentration ingroup with vitamin E intake was significantly higher than othergroups (P<۰.۰۵). Furthermore, the mean of progressive and totalmotility of sperms in group ETH and CTH was significantlylower than other groups.Conclusion: In this animal model, consumption of paternaltrans fatty acid had negative effects on normal spermatogenesisin male offspring, thus the quality and quantity of sperm weredecreased. Also, contrary to our expectations, vitamin E supplementcould not neutralize enough the negative effect of transfatty acids in this regard.

کلیدواژه ها:

Paternal Diet ، Trans Fatty Acid ، Vitamin E ، Sperm