The Preventive and Curing Effects of Ferulic Acid on Diabetes and Pituitary-Gonad Axis Hormones in Streptozotocin-Induced Diabetic Male Rats

Background: Diabetes mellitus is a common metabolic diseasewhich significantly affects the reproductive system and one ofthe complications of this disease is decreasing testosterone levelsin serum. Some studies indicated that medicinal plants mayimprove reproductive system function in diabetes. This studyinvestigated preventive and therapeutic effect of ferulic acid ondiabetes and pituitary-gonad axis hormones in streptozotocininduceddiabetic male rats.Materials and Methods: In this study, ۲۴ male Wistar rats(weighing ۲۳۵ ± ۲۵) were divided into ۴ groups( n=۶):۱- normalgroup ۲- diabetic group ۳- treatment group via ferulic acid۴-preventive group of ferulic acid (received ferulic acid for ۱۰days prior to the injection of STZ) ۵- group to received ferulicacid until the end of the period. In this study, diabetes wasinduced by streptozotocin (۴۰ mg/kg body weight i.p). ferulicacid was injected (۱۰ mg/kg). The serum glucose levels wereassessed via enzymatic colorimetric method and insulin, testosterone,LH and FSH levels in serum were assessed via Chemiluminescence method.Results: Induction of diabetes increased glucose levels and reducedinsulin levels in serum and administration ferulic acidin the treatment groups, reduced blood glucose concentrationsand increased insulin levels. Moreover induction of diabetes reducedthe levels of testosterone. Besides ferulic acid increasedtestosterone in the normal groups. Ferulic acid had no significanteffect on the LH and FSH levels.Conclusion: Ferulic acid may decrease blood glucose levelsin STZ induced diabetic rats and ferulic acid may preventiveeffects in the induction of diabetes by STZ. Ferulic acid mayincrease testosterone levels in preventive and normal mode andin normal groups these agents may androgenic properties.

کلیدواژه ها:

Ferulic Acid ، Testosteron ، LH ، FSH