Effect of Vanadium on Sperm Parameters in Offspring from Pregnant Mice

Background: Trace elements are used as alternative medicinefor decades. Some of the trace elements such as platinum, Gallium,Cupper and Vanadium used for treatment of some diseases.Vanadium is dependent on dose and has insulin mimicking andanticancer role in low dose. In this research we investigatedthe effect of Vanadium on vital parameter of sperm in offspringfrom pregnant mice.Materials and Methods: For this aim, we divided the pregnantmice into ۲ groups, control group that received nothing and Vanadiumgroup that received Vanadium ۴ mg/kg at ۸, ۱۰, ۱۲ daysof pregnancy. ۶۰ days after birth we sacrificed the male miceand removed the caudal epididym and incubated the suspensionfor ۱۰ min in incubator.Results: Our results showed that Vanadium decreased significantlysperm count and increased the sperm abnormality andsperm motility significantly compared to the control group, butdid not show any different in sperm viability with control group.Conclusion: So on the base of our research Vanadium can introduceas a good alternative medicine for protect the spermviability and motility against the destructive factors.

کلیدواژه ها:

Vanadium ، Sperm ، Mice ، Pregnancy