Effects of Cerium Dioxide Nanoparticles on In Vitro Fertilization and Embryo Development in Mice

Background: Cerium dioxide nanoparticles (CeO۲NPs) arewidely used in industry and medicine and are also used in asadditives diesel to reduce fuel consumption and Co۲ gas emissions.According to organization for economic cooperation anddevelopment, CeO۲NPs are in the priority list nanoparticles requiredargent evaluation. In the current in vitro study, the effectsof CeO۲NPs on in vitro fertilization and embryos developingrates were detected.Materials and Methods: CeO۲NPs at two different concentrations,(۱۰,۱۰۰) were added to fertilization culture medium andthen in vitro fertility, embryo development (two-cell embryoswere evaluated following ۱۲h.Results: The results showed that in vitro CeO۲NPs exposurecaused significant reduction in the percentages of fertilizationand embryo development (two-cell embryo blastocyte formation)and also increase the rate of arrested embryos in comparisonto control.Conclusion: Decreased fertilization rates may result from: ۱.CeO۲NP’s genotoxicity on gametes, ۲. a mechanical effect,disrupting gamete interaction, and ۳. oxidative stress inducedby CeO۲NP .The data obtained from its study indicated thatCeO۲NPs are toxic to the fertility and embryos developmentand precaution should be taken about human exposure.

کلیدواژه ها:

Nanoparticles ، Ceriumdioxide ، In Vitro Fertilization ، Embryo Development ، Mice