Unlocking the Heart: How Early Epigenetic and MicroRNA Changes Shape Long-Term Cardiovascular Health in Low Birth Weight Individual

Children born with low birth weight (LBW) often face an increased risk of developing cardiovascular disease (CVD) earlier in life, but the reasons behind this connection aren't fully clear. This study seeks to explore how being born with LBW might lead to heart problems down the road, with a focus on the subtle changes in our genes and the role of tiny molecules called microRNAs (miRNAs). We believe that certain genes involved in heart and blood vessel health might be altered by difficult conditions in the womb, making LBW individuals more vulnerable to CVD. Interestingly, we also propose that miRNAs might step in to protect these individuals during childhood, though this protective effect seems to fade as they get older, leading to early signs of heart disease. By identifying these key miRNAs and understanding their role, we hope to discover new ways to intervene early, possibly during adolescence, to prevent or delay heart issues. This research could lead to more personalized approaches to healthcare, helping those born with LBW live healthier lives by addressing their unique risks sooner.

کلیدواژه ها:

Low birth weight ، Cardiovascular Disease ، DNA methylation ، Histone Modifications ، Gene regulation