Novel Amides Derived from Fenofibrate and Sulfa Drugs: Synthesis, Biological Evaluation, and Molecular Docking Studies

Sulfa drugs were chemical compounds used to treat and prevent bacterial infections in humans. This study includes designing and producing a new series of amide derivatives from various sulfa drugs with fenofibrate assessed as antioxidants and anticancer agents in vitro. Their structures were definitively confirmed by the study of spectroscopic data, including Infrared spectroscopy (IR), ۱H-NMR, ۱۳C-NMR, ۲D-NMR, and elemental analysis. All products were screened in vitro against cell lines MDA-MB-۲۳۱. The cytotoxicity assay results revealed that derivatives ۵d-۵f exhibited good inhibition for MDA-MB-۲۳۱ with IC۵۰ values ۱۱۷.۱۵, ۷۹.۰۹, and ۹۸.۷۲ µg/mL, respectively. A molecular docking study of the synthetic compounds confirmed the cytotoxicity test results. In addition, the DPPH investigation revealed good antioxidant activity for the derivatives ۵a, ۵d, and ۵e with inhibition percentages of ۹۷.۹۱, ۹۴.۵۳, and ۹۵.۲۶%, respectively, compared to ascorbic acid.

کلیدواژه ها:

Amide ، Sulfa drug ، Antioxidant ، anti-cancer ، Breast ، Molecular docking