The use of mesenchymal stem cells in the treatment of premature ovarian failure

Premature Ovarian Insufficiency (POI) refers to the loss of ovarian function before the age of ۴۰. POIis one of the most common causes of infertility. Globally POI affects ۳.۵ percent of women. Some of the causes of premature ovarian failure are autoimmune disorders, genetic diseases ,environmental factors and unknown causes. In most women, the experience of infertility has a negative impact on various aspects of their quality of life and causes significant social and psychological problems. Due to the complexity of premature ovarian failure, there are various treatments such as hormone therapy, counseling, exercise and nutrition, but they have not been encouraging enough. Therefore, finding a way to restore ovarian function is of particular importance. The purpose of this review is to focus specifically on the treatment of premature ovarian failure with Mesenchymal stem cells (MSCs), and the results of the studies show positive effects on the reconstruction of the structure of the ovaries, the increase of healthy follicles and the reduction of atresia follicles.

کلیدواژه ها:

Mesenchymal Stem Cells ، Premature Ovarian Failure ، Infertility