Viral Load and the Effect to Severity of Dengue: Does It Really Matter?

The dengue virus is a prevalent viral infection transmitted by mosquitoes that is widespread across the globe. It results in ۳۹۰ million infections each year, with over ۲۵% of these being clinically evident and causing an illness. The severity of dengue illness is believed to be associated with the occurrence of secondary infection and high viral load. Dengue Hemorrhagic Fever (DHF) patients exhibit a greater viral load compared to Dengue Fever (DF) patients. There is currently lack of sufficient data on the projected viral load's impact on the severity of dengue infection. In the region of East Java, specifically in Jember, which is known for having high prevalence of dengue fever, there has been a lack of research conducted on the viral load of individuals infected with dengue. The objective of this study is to establish the correlation between viral load and the level of severity of dengue infection in Jember Regency. A cross-sectional observational analysis was conducted. The study included a total sample of ۴۸ individuals, ranging in age from ۱ to ۶۵ years, who matched the specified inclusion and exclusion criteria. Bivariate analysis using the Spearman correlation test. According to the ۲۰۱۱ WHO-SEARO diagnostic criteria, the majority of the samples (۵۲.۱%) fell into the DF group, followed by ۱۱ people (۲۲.۹%) in the DHF grade I group, ۷ people (۱۴.۶%) in the undifferentiated fever group, and ۵ people (۱۰.۴%) in the DHF grade III group. This study did not include a representative sample of individuals with DHF grade II, DHF grade IV, and expanded dengue. The Spearman correlation test revealed p-value of ۰.۶۴۵. The results of this bivariate study were determined to be insignificant due to the p-value was > ۰.۰۵. The severity of patients' dengue virus infection did not significantly correlate with their viral load.

کلیدواژه ها:

Viral load ، dengue virus infection ، severity of dengue infection