Correlation between Skin Prick Test Induration and Allergic Rhinitis Severity in Pediatric Patients: Exploring the Impact of Atopic History and Comorbidities
محل انتشار: مجله علوم دارویی و شیمی، دوره: 7، شماره: 10
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 114
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شناسه ملی سند علمی:
JR_JMCH-7-10_010
تاریخ نمایه سازی: 13 آبان 1403
چکیده مقاله:
Allergic rhinitis significantly affects children's quality of life by causing persistent symptoms that interfere with daily activities and sleep, while also exacerbating related conditions such as asthma and sinusitis. This study aims to evaluate the correlation between skin prick test (SPT) induration size and the severity of allergic rhinitis in pediatric patients, using the Combined Symptom Medication Score (CSMS) as a measure of disease severity. A cross-sectional design was employed, involving ۴۵ children aged ۱-۱۸ years with clinically confirmed allergic rhinitis due to house dust mites (HDM). Bivariate analysis revealed no significant correlation between SPT induration size and CSMS scores (r = ۰.۱۸, p = ۰.۱۲۱). However, multivariate analysis identified a weak positive correlation between disease severity and factors such as family history of atopy (r = ۰.۷۷۹, p = ۰.۰۰۶) and the presence of atopic comorbidities (r = ۰.۲۸۶, p = ۰.۰۰۷). These findings suggest that while SPT alone may not reliably predict disease severity, combining SPT results with patient-specific factors provides better insights. The study highlights the need for a multifactorial approach to assessing pediatric allergic rhinitis, integrating objective and subjective measures. Future research should focus on developing comprehensive scoring systems that incorporate clinical and biomarker data to enhance diagnostic accuracy and individualized treatment strategies. This holistic approach could improve outcomes and quality of life for pediatric patients.
کلیدواژه ها:
Allergic Rhinitis ، Skin prick test (SPT) ، House dust mites (HDM) ، Pediatric allergy ، Combined Symptom Medication Score (CSMS)
نویسندگان
Dian Hadi Purnamasari
Department of Child Health, Dr Soetomo General Academic Hospital, Surabaya, Indonesia
Zahrah Hikmah
Department of Child Health, Dr Soetomo General Academic Hospital, Surabaya, Indonesia
Anang Endaryanto
Department of Child Health, Dr Soetomo General Academic Hospital, Surabaya, Indonesia
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