AKR۱B۱۰ overexpression correlating with LINC۰۱۳۵۹ and hsa-miR-۴۴۸۲-۳p predicts worse overall survival in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the third cause of cancer-related death worldwide whileAsia accounts for highest mortality rate among the world [۱]. Also, the five-year survival rate forpatients with advanced HCC remains bleak; a reality that is largely attributable to an absence ofadequate diagnostic and prognostic biomarkers during HCC treatment.[۲] In present study, a search ofGene Expression Omnibus (GEO) database was performed to screen and download the expressionprofiles of GSE۱۴۵۲۰ and GPL۵۷۱ to obtain differentially expressed genes (DEGs) which results in amRNA, a member from aldo-keto reductase superfamily, named AKR۱B۱۰ that exhibits overexpressionin HCC compared with non-tumor tissue(all P < ۰.۰۵). Furthermore, survival analysis of HCC in thisdatabase was used for identifying AKR۱B۱۰ as a contributing factor for predicting the overall survival(OS) of HCC patients. Moreover, Protein-Protein Interaction analysis (PPI) by STRING database andKEGG pathway enrichment analysis for AKR۱B۱۰ were performed which illustrate salient role ofAKR۱B۱۰ in glucuronate interconversions. Recently, increasing evidences indicate that evolutionarilyconserved ncRNAs, particularly microRNA (miRNA) and long noncoding RNA (lncRNA), play asignificant role in diverse pathological processes [۳]. In current study, analysis has revealed AKR۱B۱۰interacts with a miRNA named hsa-miR-۴۴۸۲-۳p as well as a novel HCC-related lncRNA namedLINC۰۱۳۵۹ which has a significant upregulation in patients with liver cancer. In conclusion, evaluationof diagnostic value of AKR۱B۱۰ in tumor tissue exhibits a prospective clinical outcome in the hope ofproviding useful insights into hepatocarcinogenesis and aggressiveness.

کلیدواژه ها:

Hepatocellular carcinoma ، AKR۱B۱۰ ، miR-۱۴۵ ، LINC۰۱۳۵۹ ، biomarker