Screening of cyanobacterial bioactive peptides against viral infections

The risk of spreading viral infections increasingly threatens public health. Unfortunately, thenumber of effective and available drugs for the prevention and treatment of these types of infections islimited [۱]. Management of viral infections in the absence of prevention tools brings costs and hasserious effects on the economy and social life [۲]. The most effective way to rapidly identify antiviralcompounds is high-throughput screening of the libraries containing existing drugs or random molecules.Such analysis provides potential drug candidates, however, these efforts are usually not cost-effectiveand often time-consuming [۳]. Boosting immunity is a simple way to resist viral infection. The use ofimmune-enhancing nutrients has the potential to control viral infections by activating the immuneresponse. Cyanobacteria are a rich biological source of bioactive compounds with therapeuticimportance [۴]. In this research, among ۶۰ proteins with possible antiviral function, during ۱۰ step bystep screening, ones that had the ability to inactivate ACE۲ enzyme were selected. The ۳ selectedproteins not only represented acceptable biochemical and pharmacokinetic properties, but also hadsignificant binding energy compared to commercial antiviral drugs. Bioactive peptides are defined asspecific protein fragments that have a positive effect on body performance and health. With the help ofbioinformatics tools, it is possible to discover bioactive peptides with enhanced health-care properties,especially against viral infections. The discovery of medicinal metabolites, especially from the branchof aquatic biotechnology, has opened a promising future for us in the face of the spread of drug-resistantstrains .

کلیدواژه ها:

drug discovery ، viral infections ، bioinformatics analysis ، bioactive prospecting