Presbycusis: Ranking the genes and associated biological function

Presbycusis also known as Age-related hearing loss is a multifactorial genetic diseasedescribed as the degeneration of the auditory function by aging. This study aimed to gather all the genesassociated with Presbycusis and identify the most important genes. Additionally, we determined themost critical biological function linked to this disorder.The genes related to Presbycusis were systematically collected by literature review via PubMedadvanced rearch. We then selected articles that showed a significant association between various genesand presbycusis (p-value<۰.۰۵). We utilized the GeneMANIA Cytoscape software and CytoHubbaplugin within Cytoscape to explore the biological connections between these genes, create a visual genenetwork, identify crucial genes and also determine most important biological function. The genenetwork was created by GeneMANIA algorithm based on protein-protein interaction, geneticinteraction, co-localization and pathway.We found ۷۸ genes related to Presbycusis. “Signal transduction in absence of ligand” with q-value ۰.۰۰۹is the most significant biological function. The enrichment score is ۲۸.۳۱. The network revealed thatProtein-Protein interactions among Presbycusis-related proteins is the most prevalent biologicalconnection (۷۸%). Additional the five top gene hubs according to the CytoHubba (MCC method) are:PTK۲, CTH, DCLK۱, GRM۷ and TLR۴.This study shows that PTK۲ gene is the most important gene in Presbycusis. Our study provides insightabout the prioritization of the genes and biological function related to Presbycusis.

کلیدواژه ها:

Biological function ، gene network ، GeneMANIA ، Presbycusis