The Expression Level of SQSTM۱ Related to the Progression and Autophagy of Gastric Cancer Based on TCGA

Gastric cancer(GC) is one of the main causes of morbidity and mortality worldwide [۱].Autophagy, an intracellular homeostatic pathway, plays an important role in the physiopathologicalprocesses of human diseases such as cancer [۲]. The expression of p۶۲/SQSTM۱ (P۶۲) was consideredto evaluate the clinical significance of autophagy in GC. P۶۲ is an autophagy-related receptor proteinthat is vital in regulating multiple signaling pathways and tumorigenesis [۳]. Aim: This examinationaimed to investigate the function of the SQSTM۱ gene in the autophagy pathway involved in GC basedon bioinformatic databases. Methods: Clinical data and expression level of SQSTM۱ in patients withGC were obtained from The Cancer Genome Atlas (TCGA) based on the following selection criteriaincluding patient’s gender, race, sample types (normal and primary tumor), stage, tumor grade, andhistological subtype. All requirements were conducted on a large sample size (>۴۰۰). Datasets werethen compared to obtain the significant p-value. Results: Our results demonstrate that the expressionlevel of SQSTM۱ is increased in GC compared with normal tissue. This increase was discovered indifferent GC stages (۱-۴), different races (Asian, Caucasian), genders, tumor grades (۱-۳), and fivedifferent histological subtypes. There were no significant differences in the African-American race and۲ histological subtypes (IntAdenoMucinous and IntAdenoPapillary). Conclusion: Our study revealedthat SQSTM۱ can be considered a substantial factor in GC development with diagnostic and prognosticvalues.

کلیدواژه ها:

SQSTM۱ ، P۶۲ ، Autophagy ، The Cancer Genome Atlas (TCGA) ، Gastric Cancer