Investigation of the internal co-expression relationship evolution in chronic rhinosinusitis with nasal polyps

Chronic rhinosinusitis (CRS) is a widespread disorder affecting nearly a third of adults. It ischaracterized by persistent inflammation of the nasal and sinus lining cells. CRS exhibits aheterogeneous nature, with two major subtypes distinguished by distinct pathophysiologicalmechanisms: CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP) [۱]. Notably,up to ۶۰% of individuals with CRSwNP also experience concurrent lower airway diseases, such asasthma, which typically onset in adulthood [۲]. The main therapeutic options for CRSwNP are currentlylimited to intranasal glucocorticoid administration, sinus surgery, or a combination of both [۳]. Despitethe significant morbidity and negative impact on quality of life, our understanding of the underlyingmolecular mechanisms and specific biomarkers associated with CRSwNP remains incomplete [۴].Therefore, identifying causal genes and dysregulated pathways paves the way for novel therapeuticinterventions. The objective of the present study is a comprehensive analysis of CRSwNP-relatedtranscriptome data, aiming to decipher sophisticated molecular relations at an elevated level ofcomplexity compared to the classical pairwise interaction approach. For such purpose, we used a novelcomputational method, i.e., liquid association (LA), as a powerful tool to capture dynamic coexpressionrelationships [۵]. This approach captured the internal evolution of the co-expression relationbetween a pair of genes (X, Y) under a change in the expression profile of a third gene (Z), named theswitch gene. The results suggested that the S۱۰۰a۹, Nfe۲l۲, Ppl and Tgfbr۳ genes can be consideredpotential therapeutic targets in the CRSwNP.

کلیدواژه ها:

Chronic rhinosinusitis ، Liquid association tool ، Therapeutic targets