Solubility, mathematical modeling and thermodynamic properties of budesonide solubility in ۱-Propanol+Water from T = (۲۹۳.۲ to ۳۱۳.۲) K

Budesonide (BDS) is a corticosteroid that is used for treating asthma, rhinitis, chronicobstructive pulmonary disease (COPD), autoimmune hepatitis, and inflammatory bowel disease [۱].BDS with aqueous solubility of ۱۶ μg/mL belongs to class II of biopharmaceutical classification system.By increasing the aqueous solubility of these drugs, enhanced bioavailability, dose reduction, andenhanced efficiency can be achieved. Cosolvency as a simplest technique for the improvement aqueoussolubility of poorly soluble drugs are widely used in pharmaceutical industry. A binary mixture of ۱-propanol and water as cosolvent system was used to determine the solubility of BDS. Solubility of BDSin mass fractions of ۱-propanol/water was measured using shake-flask method. After ۴۸ h (Based onthe dissolution rate, the amount of absorption reached its maximum value after ۴۸ hours), theabsorbance of the diluted solutions was obtained with using a UV–vis spectrophotometer and theconcentrations were calculated using a previously created calibration curve (R۲= ۰.۹۹۹). In the nextstep, the solubility of BDS in binary mixtures of ۱-Propanol+Water at ۲۹۳.۲, ۲۹۸.۲, ۳۰۳.۲, ۳۰۸.۲ and۳۱۳.۲ K was investigated. Also, BDS solubility in binary mixture compositions at various temperatureswas calculated using the trained versions of the van't Hoff equation, Jouyban-Acree model and acombination of the van't Hoff equation and Jouyban-Acree model [۲]. The accuracy of these modelswas evaluated using the mean relative deviations (MRDs) as a criterion. The MRDs for the fitting ofthe solubility data of BDS in binary mixtures of ۱-propanol + water with Jouyban-Acree and Jouyban-Acree-van't Hoff models were found to be ۱۲.۳۰% and ۹.۲۳%, respectively. Finally, according to van'tHoff's and Gibb's equations, some apparent thermodynamic quantities were calculated in all the mixedsolvents, such as the dissolution enthalpy, the dissolution entropy, and the Gibbs free energy change.

کلیدواژه ها:

Solubility ، Budesonid ، ۱-Propanol ، Jouyban-Acree model ، Mathematical model