Expression data from human breast tumors and their paired normal tissues proteinprotein interaction

Breast cancer is globally the second most prevalent form of cancer which is affectingapproximately ۲.۰۹ million women.[۱] Numerous previous studies have revealed the peroxisomeproliferator-activated receptor (PPAR) signaling pathway and the risk of cancer. However, these studieshave yielded inconsistent results due to unknown role of the PPAR signaling pathway in cancerpromotion. Hence, this study aims to investigate the PPAR signaling pathway in breast cancer. TheRNA-Seq expression of a from a breast cancer was obtained from the Gene Expression Omnibus (GEO)dataset. In the training dataset (GSE۱۵۸۵۲), we chose and analyzed it by Cytoscape and Gephi software(fig۱). These analyses were done using twenty-one genes that exhibited differential expression of thePPAR signaling pathway by enrichment analysis and some have a role in cell cycle process such asTGFB۲. Therefore, the PRAR signaling pathway may be related to breast cancer progression.[۲]The result was, collectively most of the genes are related to the PPAR signaling pathway (Table ۱).Some genes are in the cell cycle such as TGFB۲.

کلیدواژه ها:

System biology ، protein-protein interaction ، breast cancer ، tumor ، gene expression